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KMID : 0387420090200010043
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Korean Society of Oriental Neuropsychiatry
2009 Volume.20 No. 1 p.43 ~ p.58
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The Effects of Hwanso-dan(Huanshaodan) Hot Water Extract & Ultra-fine Powder on Cytokine and Memory Deficit Model
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Yoon Jong-Cheon
Lee Sang-Ryong
Jung In-Chul
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Abstract
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Objectives: This experiment was designed to investigate the effect of the Hwanso-dan hot water extract & ultra-fine powder on microglia and memory deficit model
Methods: The effects of the Hwanso-dan hot water extract on expression of IL-1β, IL-6, TNF-α mRNA and production of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide were investigated. The effects of the Hwanso-dan hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and uric acid & AChE in serum of the memory deficit mice induced by scopolamine were investigated.
Results: 1. The Hwanso-dan hot water extract suppressed the expression of IL-1β, IL-6, TNF-α mRNA in BV2 microglial cell line treated by lipopolysacchaide. 2. The Hwanso-dan hot water extract suppressed the production of IL-1β, IL-6, TNF-α in BV2 microglial cell line. 3. The Hwanso-dan hot water extract & ultra-fine powder decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. 4. The Hwanso-dan hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze.
Conclusions: This experiment shows that the Hwanso-dan hot water extract & ultra-fine powder might be effective for the prevention and treatment of Memory deficit disease. Investigation into the clinical use of the Hwanso-dan hot water extract & ultra-fine powder for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Memory deficit, Alzheimer’s disease, Hwanso-dan(Huanshaodan), Hot water extract, Ultra-fine powder
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